第２回 UC San Diego – 京都大学　Joint Symposium

開催日：2016年3月14日・15日

プログラム

Time Schedule (March 14, 2016)

Plenary Session

J.R. Beyster Auditorium, Rady School of Management

8:00-9:00	Registration
9:00-9:30	Symposium Series Introduction and Welcome Vice Chancellor Sandra A. Brown, UC San Diego (Introduction) Chancellor Pradeep K. Khosla, UC San Diego (Welcome) Executive Vice-President Nagahiro Minato, Kyoto University (Leadership Remarks) Executive Vice-President Kayo Inaba, Kyoto University (International Affairs Remarks)
9:30-11:45	Breakout Session Introductions(Chairman, Paul K. L. Yu, Provost, Revelle College)
9:30-10:15	Cancer & Drug Development Scott M. Lippman, Director, Moores Cancer Center, UC San Diego “Research Highlights and New Initiatives at the Moores Cancer Center” James H. McKerrow, Dean, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego “Research and Programmatic Initiatives at the UC San Diego Skaggs School of Pharmacy & Pharmaceutical Sciences” Masakazu Toi, Professor, Breast Cancer Unit and Breast Surgery, Kyoto University “Cancer Research at Kyoto University Graduate School of Medicine and Kyoto University Hospital”
10:15-10:45	Coffee Break & Networking
10:45-11:15	Regenerative Medicine & Biology Lawrence S. B. Goldstein, Scientific Director, Sanford Consortium for Regenerative Medicine “Research Highlights and New Initiatives at the Sanford Consortium for Regenerative Medicine” Jun Takahashi, Deputy Director, Center for iPS Cell Research and Application (CiRA), Kyoto University “Current Research Activities and Future Perspectives at Kyoto University CiRA”
11:15-11:45	Advanced Energy Research Farhat N. Beg, Director, Center for Energy Research, UC San Diego “Research and Programmatic Initiatives at the UC San Diego Center for Energy Research” Satoshi Konishi, Professor, Institute of Advanced Energy, Kyoto University “Current Research Activities and Future Perspectives at Kyoto University Institute of Advanced Energy”
11:45-14:00	Lunch & Networking
14:00-16:00	Nobel Laureate Introductions & Lectures Introduction by Chancellor Pradeep K. Khosla, UC San Diego Professor Roger Y. Tsien, UC San Diego “Molecules for Multicolor Imaging and for Long-Term Memory Storage” Introduction by Executive Vice-President Nagahiro Minato, Kyoto University Professor Shinya Yamanaka, Director, CiRA, Kyoto University “New Era of Medicine with iPS Cells”
16:00-16:30	Health Sciences Overviews and Strategies Vice Chancellor David A. Brenner, UC San Diego “UC San Diego Health Sciences: Overview & Strategies” Executive Vice-President Nagahiro Minato, Kyoto University “Present and Future of Health Sciences and Biomedical Research at Kyoto University”
16:30-17:00	Networking

Time Schedule (March 15, 2016)

Breakout Session – Cancer & Drug Development

J.R. Beyster Auditorium, Rady School of Management

8:30-8:40	Opening Address Professor Scott M. Lippman, Director, Moores Cancer Center, UC San Diego
8:40-9:20	Keynote Session Introduction & Chair: Professor Quyen T. Nguyen, (UC San Diego) Professor Roger Y. Tsien, (UC San Diego) “Molecules for Imaging and Radiosensitizing Cancer”
9:20-10:10	Session 1: Molecular Imaging Chair: Professors Quyen T. Nguyen & David R. Vera, (UC San Diego) Professor Masakazu Toi, (Kyoto University) “Axillary Surgery Using Fluorescence Lymphatic Mapping for Primary Breast Cancer” Professor Anne M. Wallace, (UC San Diego) “Molecular Imaging of the Sentinel Lymph Node”
Coffee Break
10:25-11:45	Session 2: Tumor Microenvironment Chair: Professor Scott M. Lippman, (UC San Diego) Professor Makoto Mark Taketo, (Kyoto University) “Molecular Mechanisms of Colon Cancer Metastasis: Toward Clinical Applications” Professor Napoleone Ferrara, (UC San Diego) “Regulation of Angiogenesis”
Lunch Break
13:00-14:10	Collaboration Update Chair: Professor Kumar Sharma, (UC San Diego) Professor Motoko Yanagita, (Kyoto University) “Crosstalk Inside the Kidney Determines Kidney Plasticity“
14:10-14:20	Introduction to Japan Society for the Promotion of Science (JSPS) Mr. Junji Oshima, (Japan Society for the Promotion of Science) “Mechanisms of JSPS Support of International Collaborations“
14:20-15:40	Session 3: Inflammatory Response – Its Regulation and Application Chair: Professor Kayo Inaba, (Kyoto University) Professor Osamu Takeuchi, (Kyoto University) “Targeting Posttranscriptional Regulators in Inflammation” Professor Dennis A. Carson, (UC San Diego) “Prevention and Treatment of Infectious Diseases and Cancer with Synthetic Toll-like Receptor Activators”
Coffee Break
15:50-17:10	Session 4: Innate Immune Cell-Targeted Immunotherapy Chair: Dr. Yasunori Yamaguchi, (Kyowa Hakko Kirin California, Inc.) Professor Maripat Corr, (UC San Diego) “Dendritic Cells as a Target for Treatment of Autoimmune Diseases” Professor Kayo Inaba, (Kyoto University) “Initiation and Regulation of Immune Responses by Dendritic Cells”

Breakout Session – Stem Cells in Biological Discovery and Clinical Application

Duane J. Roth Auditorium, Sanford Consortium Building

7:45-8:00	Opening Address Dr. Edward W. Holmes, President, Sanford Consortium for Regenerative Medicine
8:00-9:30	Keynote Session Chair: Professor Lawrence S. B. Goldstein, (Sanford Consortium; UC San Diego) Professor Shinya Yamanaka, (CiRA, Kyoto University) “Recent Progress in iPS Cell Research and Application “ Professor Fred H. Gage, (Sanford Consortium; Salk Institute) “Modeling Human Psychiatric Diseases in Vitro“
Coffee Break
9:45-11:45	Session 1: In Vitro Disease Modelling and Epigenetics Chair: Professor Alysson R. Muotri, (UC San Diego) Professor Bing Ren, (Sanford Consortium; UC San Diego) “The 3-Dimensional Organization of Genomes” Professor Alysson R. Muotri, (Sanford Consortium; UC San Diego) “Modeling MeCP2 Disorders with iPSCs” Professor Haruhisa Inoue, (CiRA, Kyoto University) “Dissecting Neurodegenerative Diseases with iPSC Technology” Professor Hirohide Saito, (CiRA, Kyoto University) “Synthetic RNA Switches and Circuits to Detect and Purify Target Live Cells”
Lunch Break
13:00-14:45	Session 2: Cell and Tissue Differentiation and Behavior Chair: Professor Catriona H. Jamieson, (Sanford Consortium; UC San Diego) Professor Juan Carlos Izpisua Belmonte, (Sanford Consortium; Salk Institute) “Crossing Xeno-Barriers: the Hidden Dimension of Distinct Flavors of Pluripotency” Professor Kelly A. Frazer, (Sanford Consortium; UC San Diego) “Genetic Determinants of Gene Expression in a Collection of 215 Human iPSCs” Professor Dan S. Kaufman, (Sanford Consortium; UC San Diego) “Anti-Cancer Therapies Derived from Human Pluripotent Stem Cells”
14:45-15:00	Introduction to Japan Society for the Promotion of Science (JSPS) Mr. Junji Oshima, (Japan Society for the Promotion of Science) “Mechanisms of JSPS Support of International Collaborations“
Coffee Break
15:15-17:15	Session 3: Clinical Application of Cell Replacement-Based Therapies Chairs: Professors Martin Marsala, (Sanford Consortium: UC San Diego) & Alexander Norbash (UC San Diego) Professor Jun Takahashi, (CiRA, Kyoto University) “Challenges Towards Stem Cell-Based Therapy for Parkinson’s Disease” Professor Carl K. Hoh, (UC San Diego) “Quantitative Measurements of Biologic Processes with PET” Professor Martin Marsala, (Sanford Consortium, UC San Diego) “Spinal Cell-Replacement Therapies for Treatment of Spinal Traumatic Injury: An Update” Professor Catriona H. Jamieson, (Sanford Consortium, UC San Diego) “Role of RNA Editing in Leukemia Stem Cell Evolution”
17:15	Reception: Bella Vista Social Club & Caffé (adjacent to Duane J. Roth Auditorium)

Breakout Session – Advanced Energy Research in San Diego and Kyoto

The West Village, Building 1, 15th Floor

9:00-9:10	Opening Address: Professor Albert P. Pisano, Dean, Jacobs School of Engineering
9:10-10:30	Keynote Session Chair: Professor Farhat N. Beg, (UC San Diego) Professor George R. Tynan, (UC San Diego) “Energy Challenges and Fusion Research” Professor Satoshi Konishi, (Kyoto University) “Fusion Energy and its Future Deployment”
10:35-11:40	Session 1: Solar Energy and Energy Materials Chair: Professor Y. Shaya Fainman, (UC San Diego) Professor Carlos F. Coimbra, (UC San Diego) “Resource and Power Forecasting for Large Scale Solar Plants” Professor Hiroshi Sakaguchi, (Kyoto University) “New Carbon-Nanowires for Energy Utilization”
Lunch Break
13:00-13:10	Message from Japan Society for the Promotion of Science (JSPS) Mr Junji Oshima, (Japan Society for the Promotion of Science) “Mechanisms of JSPS Support of International Collaborations”
13:15-14:15	Session 2: Energy Storage Chair: Professor George R. Tynan, (UC San Diego) Professor Ping Liu, (UC San Diego) “Energy Storage Innovation for Vehicle and Grid Applications” Professor Toshiyuki Nohira, (Kyoto University) “Sodium Secondary Batteries Using Amide Ionic Liquid Electrolytes”
14:20-15:20	Session 3: Ultrafast Phenomena Chair: Professor Satoshi Konishi, (Kyoto University) Professor Y. Shaya Fainman, (UC San Diego) “Ultrafast Processing with Nanophotonics” Professor Takashi Nakajima, (Kyoto University) “Discovering a New Aspect of Laser-Nanobubble Interactions”
Coffee Break
15:50-16:50	Session 4: The Future of Energy Chair: Mr. William V. Torre, (UC San Diego) Professor David G. Victor, (UC San Diego) “A Decentralized Future for the Electric Power System?” Professor Seiichi Ogata, (Kyoto University) “Expanding Renewable Energy in Japan: Research Progress and Anticipated Solutions from Kyoto University”
16:55-17:55	Session 5: Fusion Chair: Professor Carlos F. Coimbra, (UC San Diego) Professor Farhat N. Beg, (UC San Diego) “Why Do We Need an Advanced Inertial Fusion Energy Concept?” Professor Shinichiro Kado, (Kyoto University) “Topical Studies on Plasma-Material Interactions with MAP-II Linear Divertor Simulator and Heliotron J”
17:55-18:10	Concluding Remarks Professor Farhat N. Beg, (UC San Diego) Professor Satoshi Konishi, (Kyoto University)

開催報告

初日全体セッションの会場

京都大学と米国カリフォルニア大学サンディエゴ校（以下、UC San Diego）の共催で2015年３月に京都で行われた第１回共同シンポジウム「太平洋を跨ぐ知的相互作用の新時代」でもたらされた絆や成果を引き継ぎ、第２回共同シンポジウムが2016年３月１４－１６日にカリフォルニア州ラ・ホヤ（サンディエゴ市の北隣）のUC San Diego キャンパスにて開催されました。研究者、学生、一般聴衆を含め300余名の参加者が、最先端の研究成果に触れると共に、討論や対話を通じて交流を深めました。

京都大学からは、全学から選抜された８名の若手研究者も参加しました。

共同シンポジウム参加者

Organizing Committee

Nagahiro Minato, Executive Vice-President for Research, Planning,
and Hospital Administration, Kyoto University
Kayo Inaba, Executive Vice-President for Gender Equality, International Affairs,
and Public Relations, Kyoto University
Sandra A. Brown, Vice Chancellor for Research, UC San Diego
Paul K. L. Yu, Provost, Revelle College, UC San Diego
David R. Vera, Professor, Department of Radiology; Director,
Molecular Imaging, UC San Diego
Miwako Waga, Director, International Outreach,
Office of Research Affairs, UC San Diego

Program Committee

Masakazu Toi, Professor, Department of Breast Surgery,
Graduate School of Medicine, Kyoto University
Makoto Kato-Azuma, Director and Senior Research Administrator,
URA Office (SW), Kyoto University
Izumi Yoshioka, Kyoto University Research Administration Office
David R. Vera, Professor, Department of Radiology; Director,
Molecular Imaging, UC San Diego
Martin Marsala, Professor, Department of Anesthesiology, UC San Diego;
Sanford Consortium for Regenerative Medicine
Jennifer Braswell, Executive Director, Sanford Stem Cell Clinical Center,
UC San Diego
Michelle L. Hermas, Director, International Affairs, Office of Research Affairs,
UC San Diego

1日目の全体セッションは、Sandra A. Brown UC San Diego副学長、Pradeep K. Khosla学長、湊長博理事・副学長、稲葉カヨ理事・副学長の挨拶で始まりました。

左より／稲葉カヨ理事・副学長, 湊長博理事・副学長, 山中伸弥教授, Prof. Roger Y. Tsien, Chancellor Pradeep K. Khosla, Vice Chancellor Sandra A. Brown and Vice Chancellor Suresh Subramani

次に、2日目の３つの分科会セッションについて、UC San Diego と京都大学の双方の研究者が、各分野の研究戦略や研究施設などを紹介しました。京都大学からは各セッションの序説として、「がんと創薬」では戸井雅和教授が、「幹細胞の生物学的意義と臨床適用」では高橋淳教授が、「先進エネルギー研究」では小西哲之教授が登壇しました。

戸井雅和教授

高橋淳教授

小西哲之教授

続いて、ノーベル賞受賞者のRoger Y. Tsien 教授と山中伸弥教授が分子イメージングとiPS細胞研究について基調講演を行いました。

山中伸弥教授

Prof. Roger Y. Tsien

ノーベル賞受賞教授による基調講演

さらに、David A. Brenner 副学長と、湊理事・副学長が両校の医科学分野における研究戦略と現状を紹介しました。

Vice Chancellor David A. Brenner

湊長博理事・副学長

両校における医科学分野の戦略と現況の紹介

その後、和やかな歓迎レセプションが催され、交流を深めました。

２日目は、近接した３つの会場における分科会に分かれて研究発表と討議が行なわれました。

Cancer & Drug Development
Steering Committee

Scott M. Lippman, Professor, Department of Medicine; Director,
Moores Cancer Center, UC San Diego
James H. McKerrow, Professor, Pharmaceutical Sciences; Dean,
Skaggs School of Pharmacy and Pharmaceutical Sciences
Masakazu Toi, Professor, Department of Breast Surgery,
Graduate School of Medicine, Kyoto University
David R. Vera, Professor, Department of Radiology; Director,
Molecular Imaging, UC San Diego
Tomoko Hayashi, Project Scientist, Moores Cancer Center,
UC San Diego

「がんと創薬」分科会では、再びRoger Y. Tsien 教授による最新の分子イメージング研究の講演に続いて、腫瘍内微小環境、炎症反応、免疫療法、腎臓の分子生物学などについて共同研究を含む研究成果の発表と熱心な討議がもたれました。最後のセッションでは、2014年にロレアル－ユネスコ女性科学賞を受賞した稲葉カヨ理事・副学長も登壇、講演しました。

「がんと創薬」分科会の会場

Regenerative Medicine & Biology
Steering Committee

Lawrence S. B. Goldstein, Professor,
Department of Cellular & Molecular Medicine;
Scientific Director,
Sanford Consortium for Regenerative Medicine
Catriona H. Jamieson, Associate Professor,
Department of Medicine;
Chief, Division of Regenerative Medicine, UC San Diego
Martin Marsala, Professor, Department of Anesthesiology,
UC San Diego;
Sanford Consortium for Regenerative Medicine
Jun Takahashi, Deputy Director,
Center for iPS Cell Research and Application, Kyoto University

「幹細胞」分科会では、山中伸弥教授とFred H. Gage 教授の基調講演に続き、疾患モデル、遺伝病研究と治療、細胞・組織の分化、細胞製剤治療におけるiPS細胞を含む幹細胞の利用、について先端的な研究が紹介され、活発な討議が行われました。

「幹細胞」分科会の会場

Advanced Energy Research
Steering Committee

Farhat N. Beg, Professor, Department of Mechanical
and Aerospace Engineering;
Director, Center for Energy Research, UC San Diego
Satoshi Konishi, Professor, Institute of Advanced
Energy, Kyoto University
Carlos F. Coimbra, Professor, Department of
Mechanical and Aerospace Engineering,
UC San Diego
Sasha Sachiko Yoshioka, Research Administrator,
URA Office (Uji Campus), Kyoto University

先進エネルギー研究分科会はWest Village 高層ビル１５階のラ・ホヤ全景が見渡せる会議室で開かれました。分科会はJacobs School of Engineering のPisano学部長の開会挨拶から始まり、太陽エネルギーとエネルギー材料、エネルギー貯蔵、超高速現象、未来のエネルギー、核融合などの発表が行われ、活発な議論がかわされました。

「先進エネルギー」分科会会場からのパノラマ；太平洋を望む

３日目の３月１６日には、多くの研究者が個別にセミナーや連携協議を行うと共に、２つのキャンパス見学ツアーが用意されました。

iPS細胞研究所から参加した研究者は、Sanford Consortium for Regenerative Medicine の研究施設を見学しました。

Sanford Consortium for Regenerative Medicine

エネルギー理工学研究所および経済学研究科から参加した研究者は、UC San Diego の先端的エネルギー関連施設、研究室を見学しました。UC San Diego は、使用電力の８５％以上を太陽光発電とバイオマス発電で供給していることでも広く知られており、年間800万ドル以上の経費削減を実現しているとの説明を受けました。

昼食の後、参加者はCenter for Energy Research の研究室を中心にアメリカ合衆国におけるプラズマ表面相互作用の中核センターのひとつでもあるPISCESプラズマ研究室をはじめとするエネルギー科学関連の幅広い研究室を訪問しました。