Development of humanized cardiovascular tissues from xenogeneic animals for medical use
Abulaiti Mosha
Ph.D. Student, Department of Cardiovascular Surgery, Graduate School of Medicine
Host Institution in Germany: Leibniz Research Labs for Biotechnology and Artificial Organs (LEBAO), Dept of Cardiothoracic, Transplantation and Vascular Surgery, Medizinische Hochshule Hannover(​MHH)
Year of Award: FY 2020

Host Researcher in Germany: 

  • Prof. Dr. Andres Hilfiker, Leibniz Research Labs for Biotechnology and Artificial Organs (LEBAO), Dept of Cardiothoracic, Transplantation and Vascular Surgery, Medizinische Hochshule Hannover (​MHH)

Activity 

  • Acquiring new knowledge and skills

Aims: 

  • Building a new research network in German
  • Laying the foundations for a long-term research stay
  

Motivation for application

 To learn the technology to enhance the efficiency of recellularization after implantation into an animal model

I am currently working on researches to develop xenogeneic decellularized vascular grafts as a new biocompatible medical product used in aortic surgeries. However, the efficiency of recellularization after implantation into an animal model was not sufficient and technological improvement was anticipated. I planned to learn the technology at German partner institute which is a world-wide leader of the research field and the industrialization.

That is why I submitted the DAAD-Kyoto University Partnership Programme to visit the German institute.

 

Results

New experimental techniques

During my stay at the LEBAO laboratory of the Department of Thoracic and Cardiovascular Transplantation at the Hannover Medical School, I learned new experimental techniques such as decellularization and biochemical evaluation of animal heart tissue, especially porcine heart tissue. In the laboratory under Professor Andres Hilfiker, I could interact with the members and learn new experimental techniques.

Research environment with a very good work-life balance

Furthermore, by experiencing the rich research environment of the laboratories where I visited, I was able to deepen my understanding of the differences in the style of research environments between abroad and in Japan. At last but not least, through participation in lab meetings and experiments, I was able to experience a research environment with a very good work-life balance.

 

Outlook

Through this visit, we could establish a strong research relationship with the German institute. I will further promote establishment of decellularized vascular graft with high quality and efficiency, and humanization of the grafts using human cells based on technologies we gained this time. I want to further promote research relationship by acquiring international research grants for the present research subject for worldwide clinical application of the present technology.

 


With my host researcher outside the lab

My birthday during the stay in Germany